Compared with normal tissues, TLR4 was upregulated in multiple cancers (GBM, KIRC, LGG and PAAD), and downregulated in ACC, BLCA, BRCA, COAD, CESC, DLBC, ESCA, KIRP, LIHC, LUAD, LUSC, OV, PRAD, THCA, UCEC and USE (Figure 7A). The gene discussed is TLR4; the disease is glioblastoma.