In the colorectal cancer HCT116 cell line, the increased trafficking of CTSB and uPA to the Cav of cells correlates with the expression of p11 in the cavernous body of cells, which indicates that p11 may be a binding partner of CTSB in the Cav to increase the interaction between CTSB and uPA/uPAR, thereby triggering the proteolytic cascade 113. The gene discussed is CTSB; the disease is colorectal cancer.