Our findings revealed that high levels of SGO2 expression in LUAD were associated with increased infiltration of CD4+ T cells, which are known to play a critical role in anti-tumor responses by enhancing the anti-tumor activity of immune cells and producing cytokines like TNFα and IFN-γ.40 Functionally, CD4+ helper T cells can be divided into different subsets, including Th1, Th2, Th17, and regulatory T cells (Tregs), based on their cytokine secretion profiles.41 Our results revealed that Th2 cell tumor infiltration increased while Th17 cell tumor infiltration decreased. The gene discussed is TNF; the disease is neoplasm.