Our findings revealed that high levels of SGO2 expression in LUAD were associated with increased infiltration of CD4+ T cells, which are known to play a critical role in anti-tumor responses by enhancing the anti-tumor activity of immune cells and producing cytokines like TNFα and IFN-γ.40 Functionally, CD4+ helper T cells can be divided into different subsets, including Th1, Th2, Th17, and regulatory T cells (Tregs), based on their cytokine secretion profiles.41 Our results revealed that Th2 cell tumor infiltration increased while Th17 cell tumor infiltration decreased. This evidence concerns the gene CD4 and neoplasm.