ALDOB and hereditary fructose intolerance: 6. They catalyze the reversible reaction where fructose-1,6-bisphosphate is converted into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate 6, 7. Aldolase B (ALDOB) or liver-type aldolase, is located in the liver and kidneys 8. Abnormalities in ALDOB are associated with various diseases, for instance, hereditary fructose intolerance (HFI), liver cirrhosis, hepatitis, and even cancer 9-11.