Additionally, ALS-related mutations might include those over Cu, Zn superoxide dismutase 1 (SOD1), CHCHD10, and TDP-43, which also cause various mitochondrial disturbances (Tan et al., 2014; Davis et al., 2018; Choi et al., 2019; Dafinca et al., 2020). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.