Indeed, the expression of the full-length isoform of TRPM8 located on the plasma membrane (TRPM8PM) is highly subject to androgen regulation and thus is significantly downregulated in androgen deprivation and androgen receptor (AR) loss during the late androgen-independent phase of PCa (Zhang and Barritt, 2004; Bidaux et al., 2005; Grolez et al., 2019). Here, TRPM8 is linked to posterior cortical atrophy.