TRPM8 and posterior cortical atrophy: Beside the role of the full-length TRPM, during the transition from androgen-dependent to androgen-independent phases of PCa, through an alternative splicing mechanism, the “full-length” isoform of TRPM8 gives way to a shorter isoform with typical ER localization, known as TRPM8ER (Bidaux et al., 2007).