TRPM8 and posterior cortical atrophy: A functional TRPM8ER characterized by only 4 rather than 7 transmembrane domains (TMDs) has been identified and characterized as a mediator of the Ca2+ transfer from the ER to the mitochondria in PCa epithelial cells (Figure 2) (Bidaux et al., 2018), while short non-channel TRPM8 isoforms (sM8s) with ubiquitous cytosolic localization in PCa were found to exert antagonist functions towards the full-length isoform (Peng et al., 2015; Bidaux et al., 2016).