Using an in vivo stroke model, Alim and coworkers demonstrated a shift in the GluN2A/GluN2B ratio toward the induction of GluN2A subunits and activation of the downstream prosurvival signalling pathways Akt and ERK1/2 in TRPM2 KO mice (Alim et al., 2013). This evidence concerns the gene TRPM2 and Stroke.