TRPM2 and cancer: Collectively, these studies have shown that TRPM2 supports cancer survival through a dual function: Elevated cancer ROS activates TRPM2-mediated Ca2+ influx to 1) directly couple with mitochondrial Ca2+ uptake and ATP production to promote cancer progression, and 2) potentiate the NFR2 and downstream antioxidant proteins NADPH and GSH to reduce ROS production.