In accordance, inhibition of TRPM2 protected Apoe−/− mice from high-fat diet (HFD)-induced atherosclerosis by suppressing of CD36 signaling and the activation of macrophage pro-inflammatory activity (Zong et al., 2022c), further consolidating the benefits of TRPM2 inhibition in mitigating severe inflammatory responses. This evidence concerns the gene TRPM2 and atherosclerosis.