ATF4 and acute myeloid leukemia: In acute myeloid leukemia (AML), Chen and coworkers also show that cell death mediated by knocking down TRPM2 is associated with decreased autophagy through inhibition of the CREB and ATF4, which are important transcription factors for autophagosome biogenesis, leading to a decrease in ULK1 and autophagy markers (ATGs 5, 7, and 13) (Chen et al., 2020).