TRPM2 and neoplasm: Loss of TRPM2-mediated altered mitochondrial membrane proteins was also linked to altered mitochondrial function, as it resulted in significant reductions in oxygen consumption rate (OCR) and OCR-mediated ATP production, thereby suppressing energy production and ultimately reducing tumor survival and progression in vitro and in vivo (Chen et al., 2014; Bao et al., 2016; Hirschler-Laszkiewicz et al., 2018).