TRPM2 has also been associated with Alzheimer’s disease (AD), a common neurodegenerative disorder primarily associated with the accumulation of β-amyloid (Aβ) plaques, Ca2+ overload, and increased ROS (Gibson, 2002; Leclerc et al., 2009; Zhao and Zhao, 2013; Tong et al., 2018). The gene discussed is TRPM2; the disease is Alzheimer disease.