Indeed, Miller’s group demonstrated a critical role for TRPM2-mediated Ca2+ influx in maintaining the activity of Nuclear factor (erythroid-derived 2)-Related Factor-2 (Nrf2) (Bao et al., 2019), a master transcription factor that regulates crucial genes important for antioxidant enzymes and cofactors necessary to reduce excessive ROS levels in tumor cells (Abdul-Aziz et al., 2015; Tonelli et al., 2018). This evidence concerns the gene TRPM2 and neoplasm.