TRPM2 and Alzheimer disease: Using a Barnes maze analysis, the authors further show that inhibition of TRPM2 prevents the pathological and behavioral deficits observed in older (12–15 months) APP/PS1 AD mouse models, supporting a causative relationship between Aβ and the TRPM2 activation in Aβ-induced neurotoxicity and cognitive dysfunction (Ostapchenko et al., 2015).