TRPM2 and cancer: Importantly, in rescue experiments using WT TRPM2 but not the silent E960D TRPM2 mutant, mitochondrial function and tumor survival were restored in vitro and in vivo, suggesting a direct link between TRPM2-mediated Ca2+ influx, mitochondrial bioenergetics, and cancer progression (Bao et al., 2016; Hirschler-Laszkiewicz et al., 2018).