In neuroblastoma cells, Miller’s group showed that inhibition or silencing of TRPM2 decreased hypoxia-inducible factor-1/2 (HIF)-1/2 and its downstream mitochondrial membrane proteins involved in mitophagy (BNIP3), ROS-scavenging (SOD1/2), and ATP synthesis (ETC., complexes) (Chen et al., 2014; Bao et al., 2016). The gene discussed is BNIP3; the disease is neuroblastoma.