Mechanistically, the authors provided evidence that loss of TRPM2 induces the inhibitory phosphorylation of GSK-3 via calcineurin, a known kinases in bipolar disorder (Li et al., 2010; Pandey et al., 2010), and suggest that loss of TRPM2 has a deleterious effects on BD (Jang et al., 2015). This evidence concerns the gene TRPM2 and bipolar disorder.