Indeed, deletion of PARP, a potent signal for TRPM2 activation, has been shown to be neuroprotective in males and deleterious in females (McCullough et al., 2005), where stroke-mediated cell death involves caspase-dependent apoptosis (Renolleau et al., 2007; Liu et al., 2011). The gene discussed is TRPM2; the disease is stroke disorder.