In neuroblastoma, this group demonstrated that inhibition of TRPM2 triggers cell death and is associated with a decrease in HIF-1/2 and its downstream target BNIP3, leading to the accumulation of Hsp60 and Tom20 proteins, two key indicators of decreased autophagy and mitophagy (Chen et al., 2014). The gene discussed is BNIP3; the disease is neuroblastoma.