In neuroblastoma, the authors showed that loss of TRPM2 reduced the expression of Nrf2 and expression of its regulatory proteins IQ motif containing GTPase activating protein 1 (IQGAP1) and Kelch-like ECH-associated protein 1 (Keap1), as well as the expression of Nrf2 downstream antioxidant proteins NADP+, NADPH, NAD+, NADH, and GSH, leading to ROS accumulation. The gene discussed is TRPM2; the disease is neuroblastoma.