Interestingly, the authors demonstrated that in vivo depletion of neutrophils in TRPM2 KO mice prevented LM -mediated systemic inflammation, confirming the benefit of TRPM2 activation in neutrophils for combating LM dissemination and preventing neutrophil-mediated tissue damage during Listeria infection (Robledo-Avila et al., 2020). This evidence concerns the gene TRPM2 and listeriosis.