For example, Knowles and colleagues reported that TRPM2-depleted mice were more susceptible to infection with Listeria monocytogenes (LM) and exhibited lower production of the cytokines IL -12 and IFNγ compared with WT mice, suggesting a role for TRPM2 in combating LM infections (Knowles et al., 2011). Here, TRPM2 is linked to infection.