Moreover, ectopic expression of WT -TRPM2, but not the pore-silent TRPM2 E960D mutant, in TRPM2-depleted neuroblastoma cells restored cell viability and reconstituted expression of the antioxidants NADP+, NADPH, NAD +, NADH, and GSH, while reducing ROS production, demonstrating the critical role of TRPM2-mediated Ca2+ entry in Nrf2 activity and downstream antioxidant proteins (Bao et al., 2019). The gene discussed is TRPM2; the disease is neuroblastoma.