MAPK3 and infarction: Also, intracardiac MSC pre-incubated with asprosin administration improved cardiac ejection with infarction and decreased cardiac fibrosis and reduced free radical-induced MSC damage and apoptosis after activating the ERK1/2 and PI3K/AKT pathways, upregulating SOD-2 antioxidative enzyme expression, and inhibiting further free radical production.