In this study, in which the protection of HN in myocardial damage and the role of asprosin and spexin in this effect was investigated, it was shown for the first time that asprosin and spexin might be involved in this mechanism of action as supported by biochemical and histological findings that HN has a cardioprotective effect with its application before MI. The gene discussed is SPX; the disease is myocardial infarction.