IGFBP7 and spontaneous abortion: For instance, one study suggests that a low level of insulin‐like growth factor‐binding protein 7 (IGFBP7), a member of the IGFBP family that regulates cell growth, proliferation, and differentiation, is noted in specimens of patients with RM, and knockdown of IGFBP7 inhibits matrix metalloproteinase 2 and Slug (a widely expressed transcriptional regulator belonging to the Snail family of zinc finger transcription factors) levels via the insulin growth factor‐1 receptor (IGF‐1R)‐mediated c‐Jun signaling pathway to reduce trophoblast invasion, thus inducing miscarriage (Wu et al., 2022).