Moreover, psoralen, a phytochemical compound that is traditionally used for treating psoriasis combined with ultraviolet, promotes the viability and invasion ability of trophoblasts and elevates the expression and activity of MMP‐2 and MMP‐9, as well as the nuclear accumulation and translocation of p65, suggesting that psoralen protects miscarriage by activating the nuclear factor‐κB pathway (Qi et al., 2022). This evidence concerns the gene MMP2 and spontaneous abortion.