In cotreatment groups, especially DEN + 500 ALOF + SIL, it was found that the serum level of BIL and CRP decreased significantly (p < .05) not only in comparison with DEN group but also in comparison with SIL (DEN + SIL) group (Figure 2B). The gene discussed is CRP; the disease is squamous cell intraepithelial neoplasia.