In the early phase of sepsis, characterized by an exacerbated pro-inflammatory response, sevoflurane might induce better results because it can impair recruitment from bone marrow neutrophils by reducing CXCR2 and inducing clearance from neutrophils from the alveolar compartment, which are associated with poor outcomes in acute respiratory distress syndrome induced by sepsis. This evidence concerns the gene CXCR2 and acute respiratory distress syndrome.