The results of the present study demonstrated that the factors affecting arrhythmia in patients with Omicron COVID-19 include obesity (BMI ≥24 kg/m2), fast heart rate (≥100 times/min), moderate disease severity, and WBC, CK-MB and hs-cTnI levels. Here, TNNI3 is linked to obesity due to melanocortin 4 receptor deficiency.