The factors affecting prognosis of Omicron COVID-19-infected patients with arrhythmia include advanced age (≥65 years old), history of arrhythmia, moderate disease severity, and hs-CRP, Mb and cTnI levels, which can be used to evaluate and prevent arrhythmia complications in patients with Omicron COVID-19 in the future. This evidence concerns the gene TNNI3 and cardiac arrhythmia.