On the other hand, there is a negative correlation between the levels of BDH1 and the enrichment of the H3K9bhb mark in the hepatoma cell line PLC/PRF/5, where lower levels of BDH1 led to a higher expression of a variety of genes, including some related to a poor prognosis for hepatocellular carcinoma (Zhang et al., 2021a). The gene discussed is BDH1; the disease is hepatocellular carcinoma.