NLRP3 and ischemia: In agreement with the aforementioned results, it was reported that 3 weeks feeding a KD previous to brain ischemia in mice, attenuated the ischemia-induced activation of the PERK branch of the UPR and the NLRP3 inflammasome, further suggesting that BHB can downregulate ER stress in the context of ischemia in the brain (Guo et al., 2018).