Increased protein levels of GRP78 and pPERK have been observed in postmortem brain tissue of AD patients (Hoozemans et al., 2005), and enhanced immunoreactivity to pPERK, peIF2α, and pIRE1α in neurons correlates with Tau neuropathology (Hoozemans et al., 2009). The gene discussed is MAPT; the disease is Alzheimer disease.