Moreover, AD transgenic animals with eIF2α haploinsufficiency showed reduced amyloid-β deposition and expression of BACE1 (β-secretase called β-site APP-cleaving enzyme 1), a key secretase for the production of amyloid-β peptides and a target of ATF4 (Devi and Ohno, 2014). This evidence concerns the gene EIF2A and Alzheimer disease.