A statistically substantial improvement was observed in insulin resistance, glucose/insulin ratio as well as HOMA-IR in both groups. The hormonal parameters demonstrated statistically significant improvements in both drugs concerning changes in FSH, LH, LH /FSH ratio, and testosterone levels. Lipid profiles also improved for both MI and MET. However, on comparison, the difference was not statistically significant. The gene discussed is PLOD1; the disease is Insulin resistance.