This has prompted us to study cytosolic Ca2+ signals in PACs isolated from KPC (KrasG12D/+;Trp53R172H/+;Pdx-1-Cre) mice, a genetic animal model of pancreatic carcinogenesis.12 Owing to the presence of mutations in single alleles of the Kras and Trp53 genes under the control of the Pdx1-Cre construct, KPC mice recapitulate a multistep (premalignant to cancer) model of PC development (Figure 1). Here, KRAS is linked to pachyonychia congenita.