Other approaches employ a direct injection of myoglobin or muscle extracts containing myoglobin into the bloodstream, where myoglobin can then reach the kidneys and promote AKI.5 Alcohol-induced rhabdomyolysis includes prolonged (3–4 wk) exposure to alcohol and food deprivation in animals resulting in elevation of serum CK, myoglobinuria, and muscle fiber necrosis. Here, MB is linked to acute kidney injury.