Currently, animal studies of RIAKI are based on glycerol-induction, crush injury, ischemia/reperfusion, myoglobin injection, as well as alcohol or drug-induced models of rhabdomyolysis.5,6 The most common model uses an intramuscular or intravenous injection of glycerol to promote muscle damage and subsequent release of muscle cell contents into the bloodstream. This evidence concerns the gene MB and rhabdomyolysis.