PPARG and hypertensive disorder: Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor, which controls both the bioavailability of nitric oxide and the responsiveness of the vascular smooth muscle to endothelial-derived nitric oxide, and thus plays an important regulator of blood vessel tone.6 Previous genetic studies have established the importance of PPARγ in cardiovascular diseases, including HTN.7–9