RHOBTB1 and hypertensive disorder: This is interesting because mutations in PPARγ cause human HTN.7 RhoBTB1 has also been identified in a genome wide association study to be associated with diastolic BP, and to be associated as an interacting loci in a study of over 1 million subjects.43,44 Expression of RhoBTB1 is markedly decreased in mice carrying a transgene expressing dominant negative mutation in PPARγ.12 Expression of over 100 other PPARγ-target genes were also decreased in these mice.