Since high circ_0008285 expression was associated with poor prognosis in glioma patients, and there was a positive correlation between circ_0008285 level and HMGB1 expression in glioma patients, our data support the notion that HMGB1 overexpression could contribute to the malignant phenotype of glioma cells. This evidence concerns the gene HMGB1 and central nervous system cancer.