BRCA2 and Familial adenomatous polyposis: In addition, the development of IPMNs has been related to genetic syndromes, such as familial adenomatous polyposis (FAP), BRCA2-associated hereditary breast cancer, Peutz–Jeghers syndrome, Von Hippel–Lindau (VHL) syndrome, familial pancreatic cancer (FPC), and various autoimmune diseases [2,10].