Pyruvate dehydrogenase E1 component subunit α and β (PDHA1, PDHB), pyruvate dehydrogenase protein X component (PDHX), [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme (PDK1, PDK2, PDK3), and dihydrolipoyllysine S-Acetyltransferase (DLAT) were significantly decreased in multiple brain regions of AD. The gene discussed is PDHA1; the disease is Alzheimer disease.