MDH1 and Alzheimer disease: Pearson correlation analysis found that the IDH3B, IDH3G, SUCLA2, MDH1, PDHB showed moderate negative correlations with Aβ pathology (| r| = 0.189–0.439, p < 0.05; Figure 2B), and strong negative correlations with Tau pathology (| r| = 0.653–0.847, p < 0.05; Figure 2C), implying that their reduction significantly exacerbates AD pathology.