Our study shows that both quercetin alone and quercetin combined with NAC offer effective treatment with anti-migration and anti-invasion potential on both CRC cell lines: the HT-29 colon adenocarcinoma cell line, which mutated p53 with high proliferation; and HCT-116, which wild-type p53; with microsatellite instability, which was highly aggressive but with fewer differentiae 29,30. The gene discussed is TP53; the disease is colon adenocarcinoma.