MITF and melanoma: Melanoma cells are divided into the MITF-dependent and MITF-independent two types.35 The basic expression of MITF was high in MITF-dependent melanoma cells such as M14 cells, and a significant decrease of MITF expression was observed after MITF inhibitors treatment, whereas it was difficult to observe obvious down-regulation of MITF in MITF-independent melanoma cells because of their low basic expression of MITF.