Univariate and multivariate analyses both revealed that the overall survival rate of HCC patients was significantly linked to the expression of UNC13C (p=0.004, 95% CI 1.146-2.037; p=0.042 95% CI 1.011-1.822, respectively), T status (p<0.001, 95% CI 2.240-4.189), lymph node metastasis (p<0.001, 95% CI 2.826-11.237; p=0.001, 95% CI 1.818-10.064, respectively), distance metastasis (p=0.018, 95% CI 1.208-7.255), stage (p<0.001, 95% CI 2.360-4.369 and drinking (p=0.015, 95% CI, 1.082-2.070; p=0.005, CI 1.158-2.252, respectively). The gene discussed is UNC13C; the disease is hepatocellular carcinoma.