Studies have shown that multiple inflammasomes including NLRP3, NLRC4, and apoptosis inhibitor of macrophage 1 (AIM1) among others are active in complex human CNS diseases including Alzheimer’s disease (AD), ALS, multiple sclerosis (MS) and stroke (16, 20, 46, 47). This evidence concerns the gene NLRC4 and amyotrophic lateral sclerosis.