NLRP3 and amyotrophic lateral sclerosis: Regardless of its limited translatability to broader patient populations, including other familial forms or sporadic ALS, this model captures some degree of inflammatory pathway complexity including multi-inflammasome activation and as such was used in this study in combination with human cellular systems to answer a key scientific question: In a system where multiple inflammasome pathways are active, is inhibition of NLRP3 sufficient to attenuate CNS inflammation?