While selective inflammasome inhibition is a promising therapeutic approach in monogenic autoinflammatory syndromes associated with NLRP3- or NLRC4-activating mutations (27), we hypothesize that strategies that impact multiple inflammasome pathways may hold more promise in CNS disorders like ALS where multiple inflammasomes are dysregulated (28). This evidence concerns the gene NLRP3 and amyotrophic lateral sclerosis.