Studies have shown that multiple inflammasomes including NLRP3, NLRC4, and apoptosis inhibitor of macrophage 1 (AIM1) among others are active in complex human CNS diseases including Alzheimer’s disease (AD), ALS, multiple sclerosis (MS) and stroke (16, 20, 46, 47). The gene discussed is NLRP3; the disease is early-onset autosomal dominant Alzheimer disease.