HIF1A and Lipedema: Here, no statistically different gene expression was recorded at stage I in the lipedema-affected thigh region except for hypoxia-inducible factor 1-alpha (HIF1A, Supplementary Figure S4), while expression of inflammatory marker gene interleukin-6 (IL6) and fibrosis marker collagen 6a1 (COL6A1) were elevated in abdominal biopsies of stage I patients (Figure 3B, Supplementary Figure S3B).