We observed no statistically significant effect of COVID-19 susceptibility on the increased risk of NMOSD or AQP4-NMOSD (NMOSD: OR = 1.915, 95% CI: 0.647 - 5.667, P = 0.240; AQP4-NMOSD: OR = 0.565, 95% CI: 0.099 to 3.212, P = 0.520; Supplementary Figures S1-3). The gene discussed is AQP4; the disease is COVID-19.