(52) found that hypoxic melanoma-derived small extracellular vesicles (sEVs) could enhance the angiogenic ability of CAFs by delivering the HSP90/p-IKKα/β complex to activate the IKK/IκB/NF-κB/CXCL1 signaling pathway in CAFs. The gene discussed is HSP90AA1; the disease is melanoma.