It is also of interest that some studies have shown that resveratrol at higher concentrations no longer activates Sirt-1 and its activation effect on Sirt-1 in the cell is even reversed, suggesting that the functional interaction between resveratrol and Sirt-1 in tumor cells depends on the concentration of resveratrol dose (61, 62). The gene discussed is SIRT1; the disease is neoplasm.