TP53 and colorectal carcinoma: The key observation of this work is resveratrol’s Sirt-1 inhibition at higher concentrations in HCT-116 CRC cells, thereby inducing pathways that are also down-stream of Sirt-1 signaling: (1) Resveratrol at higher concentrations (10-60μM) causes suppression of cell viability and plasticity as well as induction of apoptosis in human HCT-116 WT CRC cells, but not in human p53-deficient CRC cells (HCT-116 p53-/-).