TP53 and cancer: The natural polyphenol resveratrol, which is normally occurring in the daily human diet from sources such as berries, grapes, peanuts, and more, has a broad panel of basic bioactive effects and is widely considered to be one of the most effective agents for modulating a number of signal transduction pathways involved in inflammation, cell plasticity and chronic diseases, including cancer, by inducing apoptosis and tumor cell death in a p53-dependent manner in various cancers (22, 53–58).