Thereby, CRC cells from both cell lines were left treatment-free (TME control) or treated with resveratrol (1, 5, 10, or 20μM) or transfected with 0.5μM Sirt-1-ASO (Sirt-1 knockdown substance) or 0.5μM Sirt-1-SO (control substance). The gene discussed is SIRT1; the disease is colorectal carcinoma.