In another previous work, we demonstrated resveratrol’s ability to mediate anti-proliferative and anti-metastatic function in CRC cells when applied in lower concentration (1-5μM) via Sirt-1-dependent deacetylation of pro-inflammatory and pro-cancerogenic transcription factor NF-κB (22). The gene discussed is NFKB1; the disease is colorectal carcinoma.