To test the hypothesis that resveratrol at higher concentrations in tumors has a down-regulatory effect on Sirt-1, thereby increasing its acetylating effect on p53 and inducing apoptosis, we treated HCT-116 WT and HCT-116 p53-/-cells with different concentrations of resveratrol (1-60μM) in this present paper and demonstrated a marked concentration-dependent down-regulation of proliferation, plasticity, migration, and apoptosis in HCT-116 WT but not in HCT-116 p53-/- cells, and these results indicate p53-dependent resveratrol-induced apoptosis in CRC cells. This evidence concerns the gene SIRT1 and colorectal carcinoma.