These results demonstrate for the first time at higher resveratrol concentrations a negative reciprocal loop of down-regulation of Sirt-1 with simultaneous p53 acetylation, inhibiting plasticity and inducing apoptosis in CRC cells by promoting p53 as well as associated p21, Bax, cytochrome C, and cleaved caspase-3 signaling. This evidence concerns the gene CASP3 and colorectal carcinoma.