Investigation of the effects of resveratrol on the invasion and plasticity behavior of CRC cells considering a possible involvement of Sirt-1 or p53 signaling, HCT-116 WT or HCT-116 p53-/- cells were sown on cover glasses, and the intensity of migration within 5 days after a wound incision was documented. Here, TP53 is linked to colorectal carcinoma.