STAT3 and rheumatoid arthritis: have discovered that high expression of miR-103a in exosomes derived from macrophages (RAW264.7) can exacerbate inflammation and angiogenesis in RA mice by downregulating hepatocyte nuclear factor 4 alpha (HNF-4α) and activating the JAK/STAT3 pathway, thereby aggravating RA in mice (51).