In our study, the expression of melanogenesis-related genes TYR in the skin tissues of FHB-administered vitiligo mice was significantly increased, as were the concentrations of CHE and TYR in the serum, and the expression of inflammatory factors TNF-α and IL-6 were reduced, confirming the anti-inflammatory and melanogenesis-promoting effects of FHB. The gene discussed is IL6; the disease is vitiligo.