Our findings found that FHB not only inhibited the expression of STAT3 and p-STAT3 in the JAK-STAT signaling pathway in hydroquinone (HQ)-induced vitiligo mice but also suppressed the expression of genes of JAK-STAT pathway (including JAK1, JAK2, STAT1, STAT2), as well as the expression of inflammatory cytokines TNF-α and IL-6, which is consistent with the results predicted by network pharmacology. Here, STAT2 is linked to vitiligo.