Recent data showed a core gene signature for α-syn-reactive CD8+ T lymphocytes in PD, which includes the expression of CX3CR1, CCR5, CCR1 pro-inflammatory genes, but also genes expressed in neurons such as LRRK2, LAMP3, and aquaporin genes, previously associated with PD worsening (136). Here, LRRK2 is linked to Parkinson disease.