The increased expression of lymphocyte function-associated antigen 1 (LFA-1) integrin on infiltrating total T cells in the AD brain, and the augmented expression of Itgb2 gene, encoding for the CD18 subunit of LFA-1 molecule, in the hippocampus of a mouse model of tauopathy compared to controls suggest a role for LFA-1-intercellular adhesion molecule-1 (ICAM-1) interactions in the migration of CD8+ T cells in the CNS during AD (8, 126). The gene discussed is ICAM1; the disease is Alzheimer disease.