SOD1 and amyotrophic lateral sclerosis: Moreover, activated CD8+ T lymphocytes expressing mutant SOD-1 produce high levels of IFNγ and eliminate a subset of motoneurons in ALS through an antigen restricted, MHC-I-dependent cytotoxic pathway, suggesting a neurotoxic role for self-reactive CD8+ T cells in ALS (159) (Figure 2).