Furthermore, the immunophenotyping of TEMRA CD8+ T lymphocytes detected in the CNS of Setx KI mice revealed a CD49d+ PD-1+ CD103- profile (18), which is consistent with their peripheral origin in ALS4-like mice, suggesting pathological changes of the TRM CD8+ T cell compartment similar to those observed in MS (12) (Figure 2). Here, PDCD1 is linked to myeloid sarcoma.