HCMV infection causes remodeling of the secretory pathway, in part through viral miRNAs that target members of the endocytic pathway, such as ras-related protein rab-5 (RAB5) and synaptosomal-associated protein 23 (SNAP23), which could influence MVB exocytosis dynamics in infected cells.50 The gene discussed is RAB5A; the disease is cytomegalovirus infection.