APC and colorectal carcinoma: With our mock-up profile, we note: (1) a cluster of four CRC samples (4 TCGA and 1 CCLE) with identical case profile matching; (2) a high methylation-mutation-derived burden in TP53, APC, and KRAS genes among four TCGA samples; and (3) increased relative sensitivity in Wnt and ATR signaling pathways targeted compounds as compared to other queried compounds (Figure S6).