Our results found a significant association between nitrogen oxides and Arginase-1, a biomarker highly associated with hepatocellular differentiation, which remained statistically significant after adjusting for possible confounding factors such as alcohol intake frequency, body mass index (BMI) and cancers (breast cancer, nonmelanoma skin cancer, cutaneous squamous cell carcinoma, and basal cell carcinoma; Beta: 4.46; 95%CI: 0.83–8.08; p = 0.015). This evidence concerns the gene ARG1 and basal cell carcinoma.