In addition, Andresen et al. and Baines et al. reported that hBD1 expression is elevated in bronchia biopsies of patients suffering from asthma or COPD.372,374 This rise in hBD1 expression is associated with COPD’s pathological changes and disease severity.372,374 Similar studies were replicated with hBD2. The gene discussed is DEFB1; the disease is chronic obstructive pulmonary disease.