Estrogen also suppresses osteoclastogenesis signaling pathways to prevent osteoclast formation and RANKL‐induced differentiation.[17] Recent studies have demonstrated that estrogen acts in bone formation by promoting osteoblast formation and differentiation, thereby inducing bone formation.[18] When estrogen rapidly decreases after ovariectomy, estrogen‐induced effects diminish, resulting in the imbalance between bone formation and resorption during bone turnover.[17] The rate of bone resorption accelerates the rate of bone formation, which leads to osteoporosis. This evidence concerns the gene TNFSF11 and osteoporosis.