TWEAK/Fn14 contributes to muscle wasting associated with cancer [S50], aging [S51], denervation [S52], starvation [S53], and myotonic dystrophy [S54], but whether TWEAK and/or Fn14 levels are elevated in PD muscles and neutralizing antibodies can confer protection against PD‐associated muscle wasting is unknown and worthy of investigation. The gene discussed is TNFSF12; the disease is cancer.