BRCA1 and neoplasm: PARPi7 scores (22) were higher in BRCA1 mutated, or methylated tumours compared with BRCA1/2 wild-type tumours (P < 0.001; Fig. 2A) and in HRD-high compared with low tumors (P < 0.001; Supplementary Fig. S1C), this remained true in BRCA1/2 wild-type patients.