HDAC9 and brain ischemia: Moreover, overexpression of HDAC9 has been shown to induce oxidized low-density lipoprotein or oxygen-glucose deprivation-induced injury of cerebral VECs [13, 35], indicating the detrimental role of HDAC9 in endothelial cell survival in IA cases, especially in cases related to vascular risks, such as atherosclerosis and cerebral ischemia.