Moreover, overexpression of HDAC9 has been shown to induce oxidized low-density lipoprotein or oxygen-glucose deprivation-induced injury of cerebral VECs [13, 35], indicating the detrimental role of HDAC9 in endothelial cell survival in IA cases, especially in cases related to vascular risks, such as atherosclerosis and cerebral ischemia. The gene discussed is HDAC9; the disease is Cerebral ischemia.