To further investigate the effect of calcineurin on the regulation of c-Myc target genes, we analyzed the transcriptome profile of human diffuse large B cell lymphoma cells, HBL-1 and HT42, treated with the calcineurin inhibitor cyclosporine A (CsA) and observed that c-Myc target genes were decreased in calcineurin-inhibited cells (Fig. 2c and d). The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.