The top three downregulated genes in tumor-bearing group of female mice were Ctgf (cellular communication network factor 2, FC = 0.276, p = 0.0007), Cav2 (caveolin 2, FC = 0.305, p < 0.0014) and Tek (TEK receptor tyrosine kinase, FC = 0.32, p < 0.0021) (Fig. 4F). This evidence concerns the gene TEK and neoplasm.