Interestingly, genes associated with positive regulation of angiogenesis (e.g. Gadd45a, Dcn, Ngp, cxcl10, Hmox1,ccl11,Pgf etc.) were upregulated upon tumor growth and those associated with negative regulation of angiogenesis (e.g. Cav2, Ptprm, Mmrn2, Xdh, etc.)were downregulated, indicating that sensory neuro-vascular interaction may be sex-specific. Here, XDH is linked to neoplasm.