UBE2H and neoplasm: The top three genes downregulated in the tumor-bearing group of male mice were Gm2058 (ubiquitin-conjugating enzyme E2H pseudogene, FC = 0.211, p < 0.05), Sst (somatostatin, FC = 0.313, p < 0.001), Ms4a3 (membrane-spanning 4-domains, subfamily A, member 3, FC = 0.327, p < 0.001) (Fig. 4C).