In our study, it was not possible to collect all data related to H pylori infection and thus, we cannot know if the sHLA-G overexpression that we report here is related to the infection or the tumor and it is important to design studies that make it possible to differentiate between benign pathologies that are precursors of gastric cancer and other benign gastric pathologies to determine if the high expression of sHLA-G may be a risk factor to develop gastric cancer. Here, HLA-G is linked to infection.