We propose an initial verification of the tumor cells capability to produce HLA-G positive exosomes, in addition to release free soluble HLA-G into the extracellular space contributing to the overall expression and functional roles of HLA-G in the tumor microenvironment to delve deeper into the role of HLA-G in transmitting inhibitory signals to effector cells or activating specific signaling pathways upon fusion with the target cell membrane. This evidence concerns the gene HLA-G and neoplasm.