HLA-G and neoplasm: As HLA-G expression was significantly higher in gastric polyps, that could become malignant depending on their histology and microenvironment, and chronic inflammation is a factor that favors tumor development, it could be hypothesized that both sHLA-G in gastric polyps may be participating regulating the anti-inflammatory response in the gastric microenvironment, to favor carcinogenesis in this group of patients.