For example, the CH VAF in blood and tumor samples for the Core 1 Beta3-Galactosyltransferase-Specific Molecular Chaperone (C1GALT1C1) p.V276G variant, one of the eight potential immunosuppressive mutations in TII cells (Table 1), varies from 7.1–23.5% for tumor and 4.1–21.6% for blood samples (Fig. 3A). Here, C1GALT1C1 is linked to neoplasm.