We also found that PMA treatment induces leukemia cell differentiation by recruiting transcriptional repressor protein YY1 and histone-lysine N-methyltransferase EHMT2 (G9a) and represses the transcription of UHRF1 via histone H3 lysine 9 methylation (H3K9me)14. This evidence concerns the gene EHMT2 and leukemia.