CYP1B1 and Alzheimer disease: We evaluated the expression of AhR target genes (Ahr, Ahrr, CYP1A1, and CYP1B1) to determine whether the effect of BJIKT on the skin barrier function of AD mice fed a low AhR ligand diet was mediated by the regulation of AhR signaling using RNA-seq analysis (Fig. 4A–D).