In the culture supernatant of splenocytes, the LowAhR and LowAhR + AD groups showed a considerable increase in IL-4 (p < 0.05, LowAhR; p < 0.05, LowAhR + AD) and IFN-γ (p < 0.05, LowAhR; p < 0.001, LowAhR + AD) levels compared to the control group (Fig. 2H, I). The gene discussed is IL4; the disease is Alzheimer disease.