FIS1 and Alzheimer disease: Even though there was no significant difference for genes involved in synapsis (Fig. 6D), mitochondrial biogenesis (Fig. 6E), autophagy (Fig. 6F), and inflammation (Fig. 6I), the expression of mitochondrial structure fission gene Fis1 was significantly reduced in E4orf1 expressing mice (Fig. 6H), which is significantly increased in AD.