CD8A and neoplasm: Kaplan–Meier analysis and log-rank test (Supplemental Fig. 3) showed that low infiltration of CD8-positive cells and cells that weakly express (low-intensity) FOXP3 is a poor prognostic factor, regardless of the site of infiltration (tumor center: CD8, p = 0.0157 [e]; FOXP3, p = 0.0171 [d] and invasive front: CD8, p = 0.0149 [f] ; FOXP3, p = 0.0215 [b]).