RHOA and neoplasm: Our analysis points to malignant transformation in the primary tumour through upregulation of the group of genes that have been previously related to migration and invasion in different types of tumours, including RHOA, NLK, NFATC1, MMP7, DKK1 and CHSY1, and suppression of CTNNB1. As beta-catenin is important for cellular adhesions in epithelial tissues, we performed additional immunohistochemical analyses of tissue sections through tumorous tissue to evaluate possible changes in its expression on the protein level.