Correspondingly, we found the protein expressions of Caspase-1 and Caspase-3 p17 subunits in ITP platelets were higher than that of HCs and negatively correlated with platelet count in ITP patients, which indicated that platelets of ITP were more likely to be destroyed in Caspase-dependent pathway. Here, CASP3 is linked to autoimmune thrombocytopenic purpura.