In wild type mice, COX-2 inhibitor celecoxib had no significant influence on platelet count (Fig. 5A), while in the passive murine ITP model, the platelet counts of mice in COX-2 inhibitor group were significantly lower than the control group during the process of model induction (Fig. 5B). The gene discussed is PTGS2; the disease is autoimmune thrombocytopenic purpura.