To investigate the clinical relevance of STAT3-mTORC1 signaling in human PCa, we performed antibody staining for STAT3 activation and the mTORC1 substrates p-4E-BP1, 4E-BP1 and p-S6 in tissue microarrays (TMA) of patients diagnosed with t2DM who underwent radical prostatectomy due to organ confined PCa as described previously [46]. Here, STAT3 is linked to posterior cortical atrophy.