Remarkably, we observed metastasis to a similar extent in Ptenpc−/−, Stat3pc−/− mice as in Ptenpc−/−, Tp53pc−/−, Ptenpc−/−, Smad4pc−/− or Ptenpc−/−, KMT2C−/−, GEMMs [62, 63], indicating the importance of STAT3 signaling for metastasis risk in human PCa. The gene discussed is STAT3; the disease is posterior cortical atrophy.