STAT3 and neoplasm: Our earlier [10] and current data (Supplementary Fig. 3A) showed increased levels of TCA/OXPHOS proteins in Ptenpc−/−Stat3pc−/− tumor cells compared to Ptenpc−/− tumors, suggesting that STAT3 is a key component of dynamic mitochondrial bioenergetics and redox regulation that enables cells to maintain homeostasis and energy metabolism under tumorigenesis and metastatic energetic stress.