Since the combination of Pten and Lkb1 (Stk11) knock-out with heterozygous loss of Pten resulted in early lethality [29], we analyzed the Ptenpc+/− Stk11−/− mouse model, which showed invasive PCa and extensive lung metastases with an incidence of > 80%. This evidence concerns the gene PTEN and posterior cortical atrophy.