To confirm the STAT3/LKB1/AMPK role in lipid metabolism, we performed IHC analysis of p-ACC and FASN in mouse PCa specimens and observed decrease in p-ACC and FASN in Ptenpc−/−Stat3C/+ compared to Ptenpc−/−Stat3pc−/− specimens (Supplementary Fig. 3D). Here, STK11 is linked to posterior cortical atrophy.